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Determining the role microorganisms play in ⦠Department of Microbiology An Introduction to Clinical Microbiology Susan M. Poutanen, MD, MPH, FRCPC Microbiologist & Infectious Disease Consultant TO Public Health January 17, 2007. Pioneers of Microbiology⢠Antoni van Leeuwenhoek, DE (1673) â First observed live microorganisms (animalcules)⢠Schleiden and Schwann, DE â Formulated Cell Theory: cells are the fundamental units of life and carry out all the basic functions of living things⢠Pasteur, FR and Tyndall, UK (1861) â Finally disproved S.G. Dr.T.V.Rao MD 9 "Karyose" comes from a Greek word which means "kernel," as in a kernel of grain. Chapter 4. Course Notes for Intro to Microbiology . Chapter 13 continued. Digestion by macrophage Microbes now are digested into small antigen peptides which presented on MHC to T helper cell. Microorganisms are tiny microscopic organisms that are too small to be seen with naked eyes and thus, can only be seen with a microscope. 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